The Suwannee River is a federally designated wild river. It is the only major waterway in the southeastern United States that is still unspoiled. The Suwannee flows from the Okefenokee Swamp in southern Georgia to the Gulf of Mexico in Florida.

The Saturiwa Indians used the name Timucua, spelled thimogna, to designate specfically the Utina Indians living between the St. Johns and the Suwannee rivers.

The Suwannee River enters the Gulf of Mexico about 12 miles north of Cedar Key, approximately at latitude 29°16' north, longitude 83°08' west. The two main channels to tidewater are East Pass and West Pass. Mean tidal range at the mouth is about 2.4 feet; extreme range is about 3.4 feet.

Suwannee River, river, rising in the Okefenokee Swamp, southeastern Georgia, U.S., and meandering generally south-southwestward across northern Florida to enter the Gulf of Mexico at Suwannee Sound after a course of 250 miles (400 km). All but 35 miles (56 km) of the river's course are in Florida.